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Cayman Chemical δ-Secretase Inhibitor 11, Purity: ≥95%, CAS: 842964-18-5, 25 mg
SDP

Catalog No. 502917883
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A δ-secretase inhibitor (IC50 = 0.7 µM); selective for δ-secretase over cathepsin S, cathepsin L, caspase-3, and caspase-8 (IC50s = >200, >200, 31.86, and 86.71 µM, respectively); inhibits δ-secretase in Pala cells (IC50 = 0.8 µM); inhibits glucose-oxygen deprivation-induced cell death in primary mouse neurons at 2 µM; inhibits brain δ-secretase in wild-type mice and transgenic mice expressing human tauP301S at 10 mg/kg per day; reduces the number of cortical and hippocampal tau N368-positive neurons, restores synaptic dysfunction, and improves spatial learning and memory in transgenic mice expressing human tauP301S; reduces hippocampal Aβ deposition and attenuates cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease at 10 mg/kg

Catalog No. 50-291-7883 Supplier Cayman Chemical Supplier No. 3852425 MG
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A δ-secretase inhibitor (IC50 = 0.7 µM); selective for δ-secretase over cathepsin S, cathepsin L, caspase-3, and caspase-8 (IC50s = >200, >200, 31.86, and 86.71 µM, respectively); inhibits δ-secretase in Pala cells (IC50 = 0.8 µM); inhibits glucose-oxygen deprivation-induced cell death in primary mouse neurons at 2 µM; inhibits brain δ-secretase in wild-type mice and transgenic mice expressing human tauP301S at 10 mg/kg per day; reduces the number of cortical and hippocampal tau N368-positive neurons, restores synaptic dysfunction, and improves spatial learning and memory in transgenic mice expressing human tauP301S; reduces hippocampal Aβ deposition and attenuates cognitive deficits in the 5XFAD transgenic mouse model of Alzheimer’s disease at 10 mg/kg

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