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Medchemexpress LLC Selegiline hydrochloride | 14611-52-0 | MFCD00069299 | 99.94% | C13H18ClN | 1 ML
Supplier: Medchemexpress LLC HY1419910MM/1ML
Selegiline hydrochloride (Deprenyl hydrochloride) is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. It exhibits 450-fold selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline hydrochloride can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.
- Potent, selective, and irreversible inhibitor of MAO-B
- Exhibits 450-fold selectivity for MAO-B over MAO-A
- Increases efflux of norepinephrine, dopamine, and serotonin from rat hypothalamus
- Inhibits efflux of dihydroxyphenylacetic acid and 5-hydroxyindoleacetic acid
- Reduces cocaine self-administration in mice
- Reduces DOPAC and 5-HIAA concentrations in the frontal cortex
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