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Medchemexpress LLC Selisistat | 49843-98-3 | C13H13ClN2O | 5 MG
Supplier: Medchemexpress LLC HY154525MG
Selisistat (EX-527) is a potent and selective SirT1 (Sir2 in *Drosophila melanogaster*) inhibitor with an IC50 of 123 nM for SirT1. This compound has been shown to alleviate pathology in various animal and cell models of Huntington's disease.
- Potent and selective SirT1 inhibitor
- Alleviates pathology in multiple animal and cell models of Huntington's disease
- Inhibits the deacetylation activity of human SirT1 and Drosophila Sir2 in transfected cells
- Protective in the R6/2 mouse model of Huntington's disease
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