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Cayman Chemical SelonsertIb 10mg
Supplier: Cayman Chemical 2097210 MG
An ASK1 inhibitor (IC50 = 5.01 nM); decreases apoptosis and stellate cell activation in an in vitro 3D-human liver microtissue model of palmitic acid-induced NASH at 1 µM; sensitizes KB-C2 ABCB1-expressing epidermoid carcinoma cells to doxorubicin and paclitaxel; reduces hepatic necrosis and increases in serum TNF-α, IL-6, and CCL2 in a mouse model of LPS/D-galactosamine-induced acute liver failure at 15, 30, or 60 mg/kg
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