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Medchemexpress LLC Selumetinib (sulfate) | 943332-08-9 | 99.58% | C17H17BrClFN4O7S | 100 MG
Supplier: Medchemexpress LLC HY50706A100MG
Selumetinib (AZD6244) sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier.
- Selective, non-ATP-competitive oral MEK1/2 inhibitor
- Potency: Exhibits an IC50 of 14 nM for MEK1
- Inhibits ERK1/2 phosphorylation
- Capable of penetrating the blood-brain barrier
- Causes time- and dose-dependent reduction in DNA synthesis and cell viability
- Induces growth arrest and apoptosis
- Demonstrates anti-proliferative effects through G0/G1 arrest
- Leads to growth inhibition in various cell lines with B-Raf and Ras mutations
- Decreases growth rate of xenografts
- Induces tumor regressions
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