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Medchemexpress LLC Selumetinib sulfate | 943332-08-9 | 99.6% | C17H17BrClFN4O7S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY50706A50MG

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Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB). This product is for research use only.

  • Selective, non-ATP-competitive oral MEK1/2 inhibitor
  • Inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB)
  • Reduces DNA synthesis and cell viability
  • Induces growth arrest and apoptosis
  • Effective against cell lines with B-Raf and Ras mutations
  • Decreases growth rate and suppresses xenograft tumors in vivo
  • Observes tumor regressions in xenograft models

Catalog No. 50-003-58322


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