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Medchemexpress LLC Selumetinib (sulfate) | 943332-08-9 | 99.6% | C17H17BrClFN4O7S | 500 MG
Supplier: Medchemexpress LLC HY50706A500MG
Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).
- Selective, non-ATP-competitive oral MEK1/2 inhibitor
- Inhibits ERK1/2 phosphorylation
- Can penetrate the blood-brain barrier (BBB)
- Causes time- and dose-dependent reduction in DNA synthesis and cell viability
- Induces growth arrest and apoptosis by inactivating ERK in primary cells
- Shows anti-proliferative effects through G0/G1 arrest on H-441 and H-1437 cells
- Inhibits growth of several cell lines with B-Raf and Ras mutations
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