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Medchemexpress LLC Selumetinib (sulfate) | 943332-08-9 | C17H17BrClFN4O7S | 200 MG
Supplier: Medchemexpress LLC HY50706A200MG
Selumetinib (AZD6244) sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).
- Inhibits ERK1/2 phosphorylation
- Penetrates the blood-brain barrier
- Reduces DNA synthesis and cell viability
- Induces growth arrest and apoptosis
- Shows anti-proliferative effects through G0/G1 arrest
- Inhibits growth of cell lines with B-Raf and Ras mutations
- Decreases growth rate of xenografts
- Causes tumor regressions in xenograft models
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