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Apexbio Technology LLC Semagacestat (LY450139) 425386-60-3 200mg
Supplier: Apexbio Technology LLC A8190200
Semagacestat (LY450139 CAS 425386-60-3) is a gamma-secretase inhibitor belonging to the azadecalin class investigated for its potential in Alzheimer s disease research By selectively inhibiting gamma-secretase Semagacestat decreases the production rate of beta-amyloid (A ) peptides in both animal models (including mice beagle dogs and guinea pigs) and human subjects A is a principal component of amyloid plaques observed in the brains of Alzheimer s patients In transgenic mouse models expressing mutant human amyloid precursor protein (APP V717F) Semagacestat has been shown to slow A accumulation in the brain and reduce amyloid plaque burden dose-dependently supporting its utility as a tool compound in Alzheimer s disease pathogenesis studies
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