Cayman Chemical Senosde A 10mg

Supplier:  Cayman Chemical 2496910 MG

A dianthrone glycoside with laxative and gastroprotective activities; increases the amplitude of distal colon contractions in circular and longitudinal muscle and decreases the amplitude of proximal colon contractions in circular muscle ex vivo in mice at 30 mg/kg; increases the gastric emptying rate and increases the intestinal transport rate of a charcoal meal in mice at 100 mg/kg; increases the concentration of PGE2 in AGS gastric cells in vitro; increases gastric juice pH and decreases gastric juice secretion volume and total acid output in pylorus-ligated rats at 100 mg/kg; reduces lesion indices by 43.1 and 36% in HCl/ethanol-induced gastritis and indomethacin-induced gastric ulcer rat models, respectively, at 100 mg/kg; a non-competitive inhibitor of bovine serum monoamine oxidase in vitro (IC50 = 17 µM)

Catalog No. 50-293-4024