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Cayman Chemical SEP-0372814 10mg
SDP

Supplier:  Cayman Chemical 3283610 MG

Encompass_Preferred

A Cdk9 inhibitor (IC50 44 nM) selective for Cdk9 over Cdk1 -2 -4 -6 and -7 (IC50s 5.5 2.44 9.24 10 and 10 M respectively) and a panel of 28 additional kinases at 10 M inhibits P-TEFb-dependent transcription in vitro and de novo RNA synthesis in A549 cells at 10 M induces apoptosis in A549 and MCF-7 cancer cells prevents IL-1b-induced production of MMP-3 MMP-9 MMP-13 IL-6 IL-8 and TNF-a and NF-KB activation in SW 1353 chondrocytes delays cartilage degeneration in a mouse model of ACLT at 7.5 mg/kg prevents bone resorption in mouse models of ACLT- or LPS-induced osteoarthritis

Catalog No. 50-294-8832


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