Cayman Chemical SEP-363856hydrochlorIde 10mg

Supplier:  Cayman Chemical 3739910 MG

A TAAR1 agonist; increases intracellular cAMP levels in cells expressing TAAR1 (EC50 = 0.14 µM); an agonist of 5-HT1D and 5-HT1A receptors; decreases cAMP levels in cells expressing 5-HT1D and 5-HT1A receptors (EC50s = 0.262 and 2.3 µM, respectively); selective for these receptors over the dopamine D2L receptor (EC50s = 10.44 and 8.02 µM in cAMP and arrestin recruitment assays, respectively), as well as α2A- and α2B- adrenergic receptors, and 5-HT1B, 5-HT2A, 5-HT2C, and 5-HT7 receptors (EC50s = 6.7->10 µM in functional assays); reduces PCP-induced hyperactivity in mice at 0.3, 1, and 3 mg/kg; increases prepulse inhibition of the acoustic startle response in mice at 3, 10, and 30 mg/kg

Catalog No. 50-291-7817