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Selleck Chemical LLC Sepantronium Bromide (YM155) S1130-1g
Supplier: Selleck Chemical LLC S11301G
Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0 54 nM in HeLa-SURP-luc and CHO-SV40-luc cells does not significantly inhibit SV40 promoter activity but is observed to slightly inhibit the interaction of Survivin with XIAP YM155 down-regulates survivin and XIAP modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells Phase 2
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