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Medchemexpress LLC Sepantronium bromide | 781661-94-7 | 99.4% | 443.29 | 50 MG
Supplier: Medchemexpress LLC 50MGHY10194
Sepantronium bromide (YM-155) is a potent survivin inhibitor with an IC50 of 0.54 nM. It is intended for research use only and is not for patient treatment. This compound appears as a solid, ranging from light yellow to green yellow in color.
- Potent survivin inhibitor with an IC50 of 0.54 nM.
- Suppresses endogenous survivin expression in certain human HRPC cells.
- Inhibits various human cancer cell lines with mutated or truncated p53.
- Increases sensitivity of NSCLC cells to γ-radiation.
- Delays repair of radiation-induced double-strand breaks in nuclear DNA.
- Inhibits tumor growth in PC-3 xenografts.
- Highly distributed to tumor tissue in vivo.
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