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Medchemexpress LLC Seratrodast | 112665-43-7 | 99.6% | 5 MG
Supplier: Medchemexpress LLC HYB07745MG
Seratrodast (AA 2414) is an orally active antiasthmatic agent that functions as a thromboxane A2 receptor (TP) antagonist and a ferroptosis inhibitor. It operates by reducing lipid reactive oxygen species (ROS) production, modulating the systemic xc-/GSH/GPX4 axis, and inhibiting JNK phosphorylation and p53 expression. This compound exhibits both anti-asthmatic and anti-epileptic activities.
- Inhibits ferroptosis induced by RSL3 or Erastin in HT22 cells.
- Down-regulates the phosphorylation level of JNK.
- Inhibits ROS generation and lipid peroxidation induced by Erastin in HT22 cells.
- Shows no significant cytotoxicity at concentrations below 10 μM in HT22 cells.
- Prevents cell death in HT22 cells induced by ferroptosis inducers.
- Inhibits neuronal ferroptosis in a pentylenetetrazole-induced mouse epilepsy model.
- Reduces epileptic seizures in vivo.
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