Medchemexpress LLC Sertaconazole nitrate | 99592-39-9 | 99.2% | 500.78 | 10 MG

Supplier:  Medchemexpress LLC 10MGHYB0736A

Sertaconazole nitrate is a broad-spectrum topical antifungal agent that exhibits anti-inflammatory activity by activating a p38-COX-2-PGE2 pathway. It also acts as a microtubule inhibitor, demonstrating antiproliferative effects, inducing apoptosis and autophagy, and inhibiting cell migration.

• Broad-spectrum antifungal activity against 150 yeast strains, including six Candida species (mean MIC of 0.77 μg/mL in vitro).
• Activates p38 MAP kinase and increases PGE2 release via COX-2 in keratinocytes.
• Induces mitotic arrest by depolymerizing microtubules, leading to antiproliferation.
• Induces apoptosis through the p53 pathway and autophagy in various cell types.
• Inhibits migration of HeLa cells in a concentration-dependent manner.
• Suppresses TPA-induced ear edema in CD-1 mice, reducing inflammation.

Catalog No. 50-003-65514