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Medchemexpress LLC Sesamol | 533-31-3 | 138.12 | 500 G
SDP

Catalog No. 5000415800
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Sesamol, a constituent of sesame oil, exhibits free radical scavenging activity and shows anti-oxidant and anticancer activities. It can induce apoptosis in human liver hepatocellular carcinoma (HepG2) cells by impairing mitochondrial function and suppressing autophagy.

  • Exhibits free radical scavenging, anti-oxidant, and anticancer activities.
  • Induces apoptosis in human liver hepatocellular carcinoma (HepG2) cells.
  • Impairs mitochondrial function and suppresses autophagy.
  • Decreases anti-apoptotic protein Bcl-2 expression.
  • Improves Fas/FasL protein expression, activating tBid and caspase-8.
  • Inhibits mitophagy and autophagy via the PI3K Class III/Belin-1 pathway.
  • Significantly inhibits tumor volume and down-regulates cell proliferation marker Ki76 in vivo.
  • Increases cell apoptosis marker cleaved-caspase 3.

Catalog No. 50-004-15800 Supplier Medchemexpress LLC Supplier No. HYN1417500G
May include imposed supplier surcharges.
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Sesamol, a constituent of sesame oil, exhibits free radical scavenging activity and shows anti-oxidant and anticancer activities. It can induce apoptosis in human liver hepatocellular carcinoma (HepG2) cells by impairing mitochondrial function and suppressing autophagy.

  • Exhibits free radical scavenging, anti-oxidant, and anticancer activities.
  • Induces apoptosis in human liver hepatocellular carcinoma (HepG2) cells.
  • Impairs mitochondrial function and suppresses autophagy.
  • Decreases anti-apoptotic protein Bcl-2 expression.
  • Improves Fas/FasL protein expression, activating tBid and caspase-8.
  • Inhibits mitophagy and autophagy via the PI3K Class III/Belin-1 pathway.
  • Significantly inhibits tumor volume and down-regulates cell proliferation marker Ki76 in vivo.
  • Increases cell apoptosis marker cleaved-caspase 3.

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