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Medchemexpress LLC Sevelamer (carbonate) | 845273-93-0 | 500 MG
SDP

Supplier:  Medchemexpress LLC HY13995B500MG

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Sevelamer carbonate is an orally active, non-calcium-based phosphate binding agent primarily used in research for managing hyperphosphatemia in chronic kidney disease (CKD). It effectively lowers serum phosphorus levels while maintaining minimal impact on serum calcium or chloride levels. This buffered form of sevelamer functions as an anion-exchange resin, sharing the polymeric structure of sevelamer hydrochloride, but with carbonate substituting chloride.

  • Orally active, non-calcium-based phosphate binding agent
  • Lowers serum phosphorus levels effectively
  • Minimal effect on serum calcium or chloride levels
  • Improved, buffered form of sevelamer
  • May cause less metabolic acidosis
  • Associated with decreased low-density lipoprotein cholesterol levels
  • Decreases serum levels of gut-derived uremic toxins (in vitro)
  • Reduces serum phosphate levels in Npt2b-deficient mice (in vivo)

Catalog No. 50-003-51536


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