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Medchemexpress LLC SG3199 | 1595275-71-0 | MFCD34469130 | >98.0% | 584.66 g/mol | C33H36N4O6 | 10 MG
Supplier: Medchemexpress LLC HY10116110MG
SG3199 is a cytotoxic pyrrolobenzodiazepine (PBD) dimer that induces DNA minor-groove interstrand cross-links. It serves as a potent warhead for antibody-drug conjugate research and shows picomolar cytotoxicity in cancer cell lines. Handle with appropriate laboratory safety and storage conditions.
- Potent cytotoxicity in cancer cell lines (mean GI50 ≈ 151.5 pM).
- DNA minor-groove interstrand cross-linking mechanism.
- High DMSO solubility for in vitro assay preparation.
- Requires protection from light and storage under nitrogen at -20°C; in solvent, -80°C for long-term storage.
- Suitable for ADC payload and mechanism-of-action studies.
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