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SGC 0946, Tocris Bioscience™
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Quantity:
10 mg
50 mg
Description
Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.
To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.
Specifications
Specifications
Quantity | 50 mg |
Formula Weight | 618.57 |
Percent Purity | >99% |
Chemical Name or Material | SGC 0946 |
Safety and Handling
Recommended Storage | Store at -20°C |
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