SGC 0946, Tocris Bioscience™

Description

Highly potent and selective DOT1L inhibitor; cell permeable

Highly potent DOT1L methyltransferase inhibitor (Kd = 0.06 nM, IC50 = 0.3 nM in a radioactive assay); blocks H3K79 methylation in A431 cells and MCF10A cells. Inactive at 12 histone methyltransferases and DNMT1. Selectively kills cells transformed with the MLL-AF9 fusion oncogene in an in vitro model of leukemia; lowers levels of MLL target genes HOXA9 and Meis1.

To request the negative control for SGC0946, please fill out the SGC0649 request form on the SGC website.

Specifications

Chemical Identifiers

• CAS: 1561178-17-3
• Molecular Formula: C28H40BrN7O4
• Molecular Weight (g/mol): 618.58
• InChI Key: IQCKJUKAQJINMK-UHFFFAOYNA-N
• Synonym: 1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-tert-butyl phenyl urea, d0s9sj, sgc hplc, 1-3-2r,3s,4r,5r-5-4-amino-5-bromopyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxyoxolan-2-yl methyl-propan-2-ylamino propyl-3-4-tert-butylphenyl urea, 1-3-2r,3s,4r,5r-5-4-amino-5-bromo-7h-pyrrolo 2,3-d pyrimidin-7-yl-3,4-dihydroxytetrahydrofuran-2-yl methyl isopropyl amino propyl-3-4-2,2-dimethylethyl phenyl urea, 5-bromo-7-5-deoxy-5-3-4-1,1-dimethylethyl phenyl amino carbonyl amino propyl 1-methylethyl amino-beta-d-7h-pyrrolo 2,3-d pyrimidin-4-amine, 5-bromo-7-5-3-4-tert-butylphenyl carbamoyl amino propyl propan-2-yl amino-5-deoxy-beta-d-ribofuranosyl-7h-pyrrolo 2,3-d pyrimidin-4-amine, aw2
• PubChem CID: 56962337

• Quantity: 50 mg
• Formula Weight: 618.57
• Percent Purity: >99%
• Chemical Name or Material: SGC 0946

Safety and Handling

Recommended Storage

Store at -20°C