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Cayman Chemical SGK1 InhIbItr 10mg
SDP

Supplier:  Cayman Chemical 2565210 MG

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An inhibitor of SGK1 and SGK2 (IC50s = 4.8 and 2.8 nM, respectively); selective for SGK1 and SGK2 over SGK3 in the presence of a high concentration of ATP (IC50s = 0.442, 0.924, and 23.3 μM, respectively); only inhibits AMPK by more than 50% in a panel of 60 additional kinases at 1 μM; prevents phosphorylation of GSK3β in U2OS cells (IC50 = 1.4 μM); decreases cell viability in BYL719-insensitive HCC1954 cells when used in combination with BYL719; reduces tumor growth in an HCC1954 mouse xenograft model when administered at 50 mg/kg in combination with BYL719

Catalog No. 50-293-6376


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