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Apexbio Technology LLC SGX-523 1022150-57-7 10mM (in 1mL DMSO)
SDP

Catalog No. 5000063817
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SGX-523 (CAS 1022150-57-7) is an ATP-competitive selective inhibitor targeting the receptor tyrosine kinase c-Met (hepatocyte growth factor receptor) It effectively blocks c-Met autophosphorylation in gastric carcinoma cell line GTL16 (IC50 40 nM) and human lung cancer cell line A549 (IC50 12 nM) In vivo studies demonstrate tumor regression upon oral administration of SGX-523 in mouse xenograft models of GTL16 and human GBM cell line U87MG Moreover it inhibits phosphorylation of MEK MAPK and Akt pathways reducing proliferation migration invasion and cell cycle progression in glioma cell models SGX-523 serves as an important research tool for oncology studies involving c-Met signaling

Catalog No. 50-000-63817 Supplier Apexbio Technology LLC Supplier No. A11965.1
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SGX-523 (CAS 1022150-57-7) is an ATP-competitive selective inhibitor targeting the receptor tyrosine kinase c-Met (hepatocyte growth factor receptor) It effectively blocks c-Met autophosphorylation in gastric carcinoma cell line GTL16 (IC50 40 nM) and human lung cancer cell line A549 (IC50 12 nM) In vivo studies demonstrate tumor regression upon oral administration of SGX-523 in mouse xenograft models of GTL16 and human GBM cell line U87MG Moreover it inhibits phosphorylation of MEK MAPK and Akt pathways reducing proliferation migration invasion and cell cycle progression in glioma cell models SGX-523 serves as an important research tool for oncology studies involving c-Met signaling

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