ProSci SHMT1 Recombinant Protein

Catalog No.	Quantity
16-593-117	0.05 mg

Catalog No. 16-593-117 Supplier ProSci Supplier No. 916870050

Description

Recombinant Protein

This recombinant protein can be used for biological assays. For research use only.

Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.

Specifications

• Accession Number: P34896
• Gene ID (Entrez): 6470
• Molecular Weight (g/mol): 53.9 kDa
• Quantity: 0.05 mg
• Source: Human Cells
• Common Name: serine hydroxymethyltransferase 1
• Gene Symbol: SHMT1
• Conjugate: Unconjugated
• Species: Human
• Recombinant: Recombinant
• Protein Tag: C-6 His tag
• Sequence: Met3-Phe483
• Content And Storage: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4°C to 7°C for 2-7 days. Aliquots of reconstituted samples are stable (at -20°C for 3 months.)
• Purity or Quality Grade: >95% as determined by reducing SDS-PAGE. Endotoxin level less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test.
• Synonym: Serine Hydroxymethyltransferase Cytosolic, SHMT, Glycine Hydroxymethyltransferase, Serine Methylase, SHMT1