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Medchemexpress LLC SIAIS100 TFA | C46H51ClF5N9O7S | 25 MG
Supplier: Medchemexpress LLC 25MGHY152036A
SIAIS100 TFA is a potent BCR-ABL PROTAC degrader with a DC50 value of 2.7 nM. It is used for research into chronic myeloid leukemia (CML), exhibiting anti-proliferative activity against K562 cells with an IC50 value of 12 nM. This compound degrades BCR-ABL with high ratios at nanomolar concentrations and maintains a durable cellular response after drug removal.
- Potent BCR-ABL PROTAC degrader
- Used for chronic myeloid leukemia (CML) research
- Exhibits anti-proliferative activity against K562 cells
- Induces sustained and robust BCR-ABL degradation
- Degrades G250E/T315I mutation dose-dependently
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