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AdipoGen Sibiriline
SDP

Supplier:  AdipoGen AGCR10160M005

Encompass_Preferred

Chemical. CAS 1346526-26-8. Formula C13H10N2O. MW 210.2. Specific competitive RIPK1 inhibitor in vitro IC50=1.03µM. Binds to human RIPK1 adenosine triphosphate-binding site and locks it in an inactive conformation to block necroptosis. Necroptosis contributes to the pathogenesis of several inflammatory diseases including ischemic reperfusion injury, acute pancreatitis, sepsis, neurodegeneration, viral infection and liver diseases. Inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells EC50=1.2µM. Does not block caspase-dependent apoptosis induced by TRAIL, FasL or staurosporine. Protects mice from concanavalin A-induced hepatitis in vivo.

Catalog No. 50-256-2354


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