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Cayman Chemical SID 3712249 50mg
Supplier: Cayman Chemical 2972350 MG
An inhibitor of miR-544 biogenesis; increases MTOR mRNA expression and decreases the mRNA expression of the genes encoding miR-544, HIF-1α, and ATM in MDA-MB-231, MCF-7, and MCF-10A cells under hypoxic conditions at 20 nM; induces apoptosis in MDA-MB-231 cells in a hypoxia- and mTOR-dependent manner at 20 nM; enhances the senstivity of MCF-7 and MDA-MB-231 cells cultured under hypoxic conditions to 5-FU-induced decreases in cell viability at 20 nM; reduces tumor growth in an MDA-MB-231 mouse xenograft model
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