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Apexbio Technology LLC Sildenafil 139755-83-2 200mg
Supplier: Apexbio Technology LLC A3817200
Sildenafil (CAS 139755-83-2) is a small molecule inhibitor of phosphodiesterase type 5 (PDE5) By selectively blocking PDE5 activity sildenafil increases intracellular levels of cyclic guanosine monophosphate (cGMP) thereby modulating smooth muscle relaxation The compound exhibits an IC50 value of 5 22 nM against PDE5 indicating high potency in enzymatic assays Sildenafil is widely utilized in biomedical research to study cGMP signaling pathways and vascular smooth muscle physiology as well as to evaluate mechanisms underlying vasodilation and related pathophysiological conditions
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