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Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 1 G
Supplier: Medchemexpress LLC HY150251G
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. It is intended for research use only.
- Potent PDE5 inhibitor
- IC50 of 5.22 nM against PDE5
- Potentiates ERK1/ERK2 phosphorylation
- Increases cell proliferation
- Increases intracavernosal pressure and ICP/blood pressure ratio in dog models
- Decreases the number of TL+-cells
- Reduces microglia/macrophages in pMCAo models
- Decreases flap necrosis in preclinical animal models
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