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Medchemexpress LLC Sildenafil | 139755-83-2 | C22H30N6O4S | 50 MG
Supplier: Medchemexpress LLC HY1502550MG
Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM. This compound is intended for research use only and is not sold to patients.
- Potent phosphodiesterase type 5 (PDE5) inhibitor
- Cited in numerous scientific publications
- Potentiates phosphorylation of ERK1/ERK2 and increases cell proliferation in vitro
- Significantly increases intracavernosal pressure in a dog model of erection
- Reduces microglia/macrophages in a pMCAo mouse model
- Decreases flap necrosis in preclinical animal models by increasing growth factors
- Under investigation in clinical trials for various conditions including Heart Failure and Erectile Dysfunction
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