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Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 5 MG
Supplier: Medchemexpress LLC HY50855B5MG
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor (IC50 values of 1 nM against CK2α and CK2α'). It induces cell-cycle arrest and selectively causes apoptosis in cancer cells, attenuates PI3K/Akt signaling, and demonstrates antiproliferative activity correlating with CK2α catalytic subunit expression. It also prevents leukemic cells from engaging a functional UPR to buffer proteotoxic stress and decreases pro-survival ER chaperon BIP/Grp78 expression.
- Causes cell-cycle arrest
- Induces apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Exhibits antiproliferative activity
- Prevents leukemic cells from engaging a functional UPR
- Decreases pro-survival ER chaperon BIP/Grp78 expression
- Induces cytotoxicity
- Suppresses CK2-mediated PI3K/Akt/mTOR signaling pathways
- Demonstrates robust antitumor activity in murine xenograft models
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