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Medchemexpress LLC Silmitasertib sodium salt | 1309357-15-0 | 99.92% | C19H11ClN3NaO2 | 1 G
SDP

Supplier:  Medchemexpress LLC HY50855B1G

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Silmitasertib sodium salt is an orally bioavailable, highly selective and potent CK2 inhibitor, with IC50 values of 1 nM against CK2α and CK2α'. It induces cell-cycle arrest and selectively induces apoptosis in cancer cells, attenuates PI3K/Akt signaling, and its antiproliferative activity correlates with CK2α catalytic subunit expression. It also prevents leukemic cells from engaging a functional UPR and decreases pro-survival ER chaperon BIP/Grp78 expression.

  • Highly selective and potent CK2 inhibitor (IC50 of 1 nM against CK2α and CK2α')
  • Induces cell-cycle arrest and selective apoptosis in cancer cells
  • Attenuates PI3K/Akt signaling and suppresses CK2-mediated PI3K/Akt/mTOR signaling
  • Exerts anti-proliferative effects in hematological tumors
  • Prevents leukemic cells from engaging a functional UPR and decreases pro-survival ER chaperon BIP/Grp78 expression

Catalog No. 50-003-58772


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