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Medchemexpress LLC Silmitasertib sodium salt (CX-4945 sodium salt) | 1309357-15-0 | 99.9% | C19H11ClN3NaO2 | 50 MG
Supplier: Medchemexpress LLC HY50855B50MG
Silmitasertib sodium salt is an orally bioavailable, highly selective, and potent CK2 inhibitor, demonstrating IC50 values of 1 nM against CK2α and CK2α'. This compound induces cell-cycle arrest and selectively promotes apoptosis in cancer cells. It also attenuates PI3K/Akt signaling, decreases pro-survival ER chaperon BIP/Grp78 expression, and suppresses activation of CK2-mediated PI3K/Akt/mTOR signaling pathways in hematological tumors.
- Orally bioavailable and potent CK2 inhibitor
- Highly selective against CK2α and CK2α' (IC50 1 nM)
- Induces cell-cycle arrest and apoptosis in cancer cells
- Attenuates PI3K/Akt signaling
- Suppresses CK2-mediated PI3K/Akt/mTOR signaling
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