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Bio X Cell InVivoSIM anti-human PD-1 Antibody, Human IgG4, 150 kDa, Unconjugated
Supplier: Bio X Cell SIM0003R001MG
This biosimilar antibody uses Nivolumab's variable regions, reacting with human PD-1 (CD279). It is a humanized IgG4 monoclonal antibody with an S228P hinge mutation for enhanced stability and reduced non-specific binding. PD-1, a 50-55 kDa cell surface receptor, is crucial for peripheral tolerance and inhibiting T-cell activation.
- Biosimilar antibody.
- Nivolumab variable regions.
- Reacts with human PD-1 (CD279).
- Humanized IgG4 monoclonal antibody, S228P mutation.
- Enhanced stability, reduced non-specific binding.
- Purity ≥95%; 0.2 μm sterile filtration.
- 150 kDa molecular weight.
- PBS, pH 7.0 formulation (no stabilizers/preservatives).
- Endotoxin ≤0.5 EU/mg.
- Animal-free production; Protein A purified.
- Negative for murine pathogens.
- Store at 4°C; do not freeze.
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