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Apexbio Technology LLC Simvastatin (sodium salt)(Synonyms: Simvastatin sodium, Simvastatin sodium salt, Sodium simvastatin, Synvinolin sodium), 10mg, CAS: 101314-97-0.
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Supplier:  Apexbio Technology LLC C442610

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Simvastatin (sodium salt) (CAS 101314-97-0) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase a critical enzyme controlling the rate-limiting step in cholesterol biosynthesis It binds with high affinity to HMG-CoA reductase exhibiting a Ki of approximately 0 12 nM In hepatocyte-derived Hep G2 cells simvastatin demonstrated potent suppression of cholesterol biosynthesis reducing the incorporation of radiolabeled acetate into sterols (IC50 15 nM) Animal studies with orally administered simvastatin indicated marked reduction in plasma cholesterol levels validating its utility in experimental models exploring cholesterol regulation and lipid metabolism

Catalog No. 50-000-61358


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