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Cayman Chemical Simvastatin sodium salt
Supplier: Cayman Chemical 100103455 MG
An HMG-CoA reductase inhibitor (Ki = 0.12 nM); reduces plasma cholesterol levels in rats and dogs at 1.2 and 8 mg/kg, respectively; suppresses TNF-induced NF-κB activation (IC50 = ~13 µM) and potentiates apoptosis in human myeloid leukemia cells; inhibits GPX4, increases MDA levels, and induces ferroptosis in MDA-MB-231 and MCF-7 breast cancer cells
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