Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Simvastatin (sodium salt)(Synonyms: Simvastatin sodium, Simvastatin sodium salt, Sodium simvastatin, Synvinolin sodium), 5mg, CAS: 101314-97-0.
Supplier: Apexbio Technology LLC C44265
Simvastatin (sodium salt) (CAS 101314-97-0) is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase a critical enzyme controlling the rate-limiting step in cholesterol biosynthesis It binds with high affinity to HMG-CoA reductase exhibiting a Ki of approximately 0 12 nM In hepatocyte-derived Hep G2 cells simvastatin demonstrated potent suppression of cholesterol biosynthesis reducing the incorporation of radiolabeled acetate into sterols (IC50 15 nM) Animal studies with orally administered simvastatin indicated marked reduction in plasma cholesterol levels validating its utility in experimental models exploring cholesterol regulation and lipid metabolism
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?