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Cayman Chemical SIN-1chlorIde 50mg
Supplier: Cayman Chemical 8222050 MG
A TRPC6 inhibitor (IC50 13 nM for the mouse channel) selective for TRPC6 over TRPC3 and TRPC7 (IC50s 1100 and 550 nM respectively for the mouse channels) inhibits TRPC6-mediated reporter gene expression in HEK293T cells expressing mouse TRPC6 at 100 250 and 500 nM decreases myocardial interstitial fibrosis in a mouse model of hypertrophic cardiomyopathy induced by transaortic constriction at 30 mg/kg reduces unilateral ureteral obstruction-induced renal fibrosis in mice increases survival decreases myocardial fibrosis and improves grip strength in a mouse model of DMD at 30 mg/kg
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