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Genscript Corporation SIRP Fc Chimera Human
Supplier: Genscript Corporation Z034201
Signal regulatory protein alpha (SIRP designated CD172a) is also known as CD172 antigen-like family member A (CD172a) also called SHPS-1 (SHP substrate 1) and previously MyD-1 (Myeloid/Dendritic-1) which is a monomeric about 90kDa type I transmembrane glycoprotein that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily SIRP is Ubiquitous and highly expressed in brain SIRPA/CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6 PTPN11 and other binding partners from the cytosol to the plasma membrane SIRPA/SHPS-1 supports adhesion of cerebellar neurons neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function by similarity SIRP recognition of surfactants SP-A and SP-D in the lung can inhibit alveolar macrophage cytokine production
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