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AdipoGen anti-Sirtuin 2 (human), mAb (S2R233-1) (100 µg)
Supplier: AdipoGen AG20A0076C100
Monoclonal Antibody. Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S2R233-1. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington’s and Parkinson’s disease.
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