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AdipoGen anti-Sirtuin 6 (human), mAb (S6R82-2) (100 µg)
Supplier: AdipoGen AG20A0091C100
Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.
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