STEMCELL Technologies Sirtinol, Size: 10 mg

Supplier:  STEMCELL Technologies 73824

Sirtinol is a cell-permeable inhibitor of sirtuin NAD+-dependent histone deacetylases (HDACs), including yeast Sir2p (IC₅₀ = 68 μM; Grozinger et al.), human SIRT1 (IC₅₀ = 131 μM; Schuetz et al.), and SIRT2 (IC₅₀ = 38 μM; Grozinger et al.). It does not inhibit human HDAC1 activity (Grozinger et al.). Sirtinol also activates the auxin signaling pathway in Arabidopsis (Dai et al.).IMMUNOLOGY· Suppresses inflammatory signaling in human dermal microvascular endothelial cells (Orecchia et al.).CANCER RESEARCH· Enhances apoptosis and cell death in leukemic cells, but not in healthy leukocytes and hematopoietic progenitors (Cea et al.).· Induces senescence-like growth arrest in human cancer cell lines MCF-7 and H1299 (Ota et al.; Wang et al.).

Catalog No. 50-197-6135

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov