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Apexbio Technology LLC Sivelestat (ONO-5046) 127373-66-4 200mg
Supplier: Apexbio Technology LLC B6189200
Sivelestat (ONO-5046) is a selective inhibitor of neutrophil elastase with an IC50 value of 44 nM Neutrophil elastase a serine protease secreted by activated neutrophils can degrade extracellular matrix components and contribute to tissue injury in inflammatory diseases such as rheumatoid arthritis emphysema acute respiratory distress syndrome (ARDS) and septic shock Sivelestat inhibits human neutrophil elastase in a competitive manner and similarly reduces the activity of leukocyte elastases from rodents In animal sepsis models sivelestat attenuates renal dysfunction reduces inflammatory markers like NGAL and increases survival rates Clinically this compound is utilized for managing acute lung injury associated with systemic inflammatory response syndrome and ARDS
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