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Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.81% | 987.96 | 25 MG
Supplier: Medchemexpress LLC 25MGHY147330A
SJ1008030 TFA is a JAK2 PROTAC designed to selectively degrade JAK2. This compound has demonstrated potent inhibitory effects on MHH-CALL-4 cell growth with an IC50 of 5.4 nM, making it a valuable tool for leukemia research.
- Selectively degrades JAK2.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Useful for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating the inhibition of the JAK-STAT signaling pathway.
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