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Medchemexpress LLC SJ10542 | 2789678-92-6 | 99.3% | C41H46N12O5S | 50 MG
SDP

Supplier:  Medchemexpress LLC HY14569650MG

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SJ10542 is a potent and selective JAK2/3 PROTAC degrader. In PDX cells lSJBALL020589, SJ10542 has DC50 values of 14 and 11 nM for JAK2 and JAK3, respectively. It exhibits antitumor activity and can be used for the research of hematological malignancies and autoimmune diseases.

  • Potent and selective JAK2/3 PROTAC degrader
  • Exhibits antitumor activity
  • Useful for research of hematological malignancies and autoimmune diseases
  • Degrades JAK2 (DC50: 24 nM), JAK3, and GSPT1 in MHH-CALL-4 cells
  • JAK2 DC50: 14 nM
  • JAK3 DC50: 11 nM
  • JAK2-fusion ALL DC50: 24 nM
  • CRBN recruiter

Catalog No. 50-003-53401


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