Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC SJB2-043 63388-44-3 5mg
Supplier: Apexbio Technology LLC A38235
SJB2-043 (CAS 63388-44-3) is a small molecule inhibitor of ubiquitin-specific protease 1 (USP1) a deubiquitinating enzyme involved in the regulation of DNA repair by deubiquitinating key proteins in the Fanconi anemia (FA) pathway SJB2-043 exhibits an IC50 of 0 544 M for USP1 In cellular models such as K562 leukemia cells and primary AML cells SJB2-043 reduces USP1 levels and promotes proteasomal degradation of ID1 as well as decreasing ID2 and ID3 protein levels Treatment with SJB2-043 also increases Ub-FANCD2 and Ub-PCNA in HeLa cells reflecting modulation of DNA repair processes This compound serves as a valuable tool for studies investigating USP1 function and the regulation of ID proteins in cancer and stem cell biology
This item is not returnable.
View return policy
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?