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Medchemexpress LLC Sjf-1521 | 2230821-40-4 | >98.0% | C57H61ClFN7O9S | 10MG
Supplier: Medchemexpress LLC HY13186510MG
SJF-1521 is a selective EGFR PROTAC degrader that induces proteasomal degradation of EGFR in OVCAR8 cells and is used for tumor research and cellular pathway studies. It couples an EGFR-binding ligand to a VHL-recruiting moiety to promote targeted ubiquitination and clearance of the receptor.
- Selective EGFR degrader enabling modulation of receptor levels.
- Demonstrated to induce EGFR degradation in OVCAR8 cells.
- Dual mechanism: EGFR binding and VHL recruitment for proteasomal degradation.
- Suitable for tumor biology and signal transduction research in cell models.
- Reported high purity suitable for biochemical and cellular assays (≥98% HPLC).
- Available in multiple research-scale pack sizes for experimental flexibility.
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