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Medchemexpress LLC SK-575 | 2523016-96-6 | 99.9% | 876.97 | 25 MG
Supplier: Medchemexpress LLC 25MGHY139156
SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. It potently inhibits the growth of cancer cells bearing BRCA1/2 mutations.
- Potently inhibits the growth of cancer cells bearing BRCA1/2 mutations.
- Shows good PARP1 degradation activity in cancer cell lines.
- Effectively induces the formation of γH2AX in MDA-MB-436 and Capan-1 cells in a dose-dependent manner.
- Significantly inhibits tumor growth in HR-deficient xenograft models.
- Achieves sufficient plasma exposure and effectively induces PARP1 degradation in tumor tissue.
- Well tolerated in animal models.
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