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Apexbio Technology LLC SKF 525A (hydrochloride) 62-68-0 1g
Supplier: Apexbio Technology LLC C35601000
SKF 525A (hydrochloride CAS 62-68-0) is a small-molecule inhibitor of cytochrome P450 (CYP) enzymes It modulates CYP-mediated metabolic pathways by inhibiting several isoforms including CYP2B6 CYP2C9 CYP2C19 CYP2D6 and CYP3A with limited impact on CYP1A2 CYP2A6 and CYP2E1 When assessed in human liver microsomes SKF 525A demonstrates CYP-dependent N-deethylation and exhibits inhibitory potency in the micromolar range In animal models it non-specifically disrupts sympathetic ganglia and adrenal medulla signaling possibly by stabilizing postsynaptic membranes SKF 525A is commonly used to study drug metabolism and CYP-mediated biotransformation in preclinical settings
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