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Cayman Chemical SKF 86466hydrochlorIde 10mg
SDP

Supplier:  Cayman Chemical 1195310 MG

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An α2-AR antagonist (Kis = 9.4, 16, and 20 nM for α2A, α2B, and α2C receptors, respectively); selective for α2-ARs over α1-ARs (Kis = 449, 485, and 126 nM for α1A, α1B, and α1D receptors, respectively); inhibits contractions in rabbit aorta and canine saphenous vein induced by norepinephrine or B-HT 920, respectively (KBs = 600 and 42 nM, respectively); decreases diastolic blood pressure in DOCA-salt hypertensive, spontaneously hypertensive, and 2K-1C renal hypertensive rats at 2 mg/kg, i.v.; reduces reserpine-induced muscle rigidity in a mouse model of Parkinson's disease at 1 mg/kg

Catalog No. 50-295-5118


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