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Medchemexpress LLC SKI-178 | 1259484-97-3 | 99.3% | 10 MG
Supplier: Medchemexpress LLC HY1289210MG
SKI-178 is a potent inhibitor of both sphingosine kinase-1 (SphK1) and SphK2. It exhibits cytotoxicity at IC50 concentrations ranging from 0.1 to 1.8 μM in various cancer cell lines, including those resistant to multiple agents. This compound has been shown to induce apoptosis in human acute myeloid leukemia cell lines through a CDK1-dependent mechanism.
- Potent sphingosine kinase-1 and SphK2 inhibitor
- Exhibits cytotoxicity in various cancer cell lines
- Induces apoptosis in a CDK1-dependent manner
- Inhibits leukemic progression in an MLL-AF9 mouse model
- Suitable for in vitro and in vivo studies
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